Anti-inflammatory activities of compounds isolated from Amanita caesarea collected in Lam Dong province

Five natural secondary metabolites as cinnamic acid (1), (+)-catechin (2), (-)-epicatechin (3), p-coumaric (4), and ferulic (5) were isolated from Amanita caesarea based on anti-inflammatory activity-guided extraction. Their structures (1-5) determined by NMR spectra well comparison with previously reported literature. Compounds 3 5 have been A. for the first time. The activity through inhibition of nitric oxide (NO) production isolates was evaluated. Among them, compounds 2 exhibited strong inhibitory IC50 values 4.8 5.7 μM, respectively. 4 18.4 9.6 respectively showed moderate activity. results proposed that might exert effects due to its mainly NO-inhibitory constituents